So, there must be a reason why it is present in every society and human culture of all time...

And then:
Drugs are not bad. Drugs are a chemical compound. The problem is when those who take drugs consider it a license to act like assholes.”
Frank Zappa

And then, what is a drug?:
Every form of addiction is bad, no matter whether the narcotic be alcohol or morphine or idealism.
Carl Gustav Jung

Let's not forget the hypocrisy of the "right-thinking":
Instead of wasting all these energies and efforts directed at making war on drugs, why not pay attention to drugs that could end the war?
Albert Hofmann

And finally:
It is difficult to live without opium after knowing it, because it is difficult, after knowing opium, to take the earth seriously. And unless one is a saint, it is difficult to live without taking the earth seriously.
Jean Cocteau

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