Matt Groening
Futurama

The highly acclaimed Matt Groening is not only the father of all comic-satirical cartoons (namely the pioneering Simpsons) but has given birth to another creature worthy of the utmost respect when compared to its older brother: Futurama.
Brief summary for those who have never seen it (although probably there isn't anyone): young Fry, a pizza delivery boy, is accidentally sent forward a thousand years into the future. Upon awakening, he finds himself in contact with a hyper-technological world populated by humans, robots, and aliens of the most diverse types where nations no longer exist, but everything is unified in the single state of "Earth." In this context, he befriends an alcoholic robot, falls in love with a one-eyed mutant, and ends up working, once again as a delivery boy, for the transportation company of his very old descendant (great-great-great-nephew) who works as a scientist. Besides these main characters, there are other protagonists, some more important than others, among whom the mythical Dr. Zoidberg must absolutely be mentioned, an "omnivorous" alien in the form of a crustacean with no knowledge of how human anatomy and medical care work. The series is primarily based on the adventures experienced by the protagonists on their parcel delivery missions across various planets scattered throughout the universe.
It is practically impossible not to fall in love with this series if you follow it consistently without losing track. Indeed, it cannot be fully appreciated if watched sporadically; undoubtedly many episodes are fantastic in themselves, even without placing them in a broader context, but the work reveals all its genius only by following the episodes step by step. Only in this way can one grasp all the nuances behind a single, great choral story that shows clues about the ending from the first episode. But beyond this aspect, which I personally preferred, the series can very well live on the splendid irony that hits the lifestyles of the twentieth century, the satire directed at prominent figures of our time (especially the poor Richard Nixon), whose still-talking heads are preserved in a museum inside special containers, and the countless references to be found here and there in all episodes, some for real connoisseurs. But also (why not) on the many purely comic situations found in all cartoons of the genre, which bring lightness to the viewing (in these, the spoiled, evil, and selfish robot Bender is undoubtedly the protagonist). There are also moments of reflection that sometimes add a bitter note to our smiles and make us question the consequences of the relentless pursuit of progress and success at all costs. There is also a romantic base, shown sporadically, concerning the poor Fry and his love for the elusive Leela. Undoubtedly, the charisma and excellent characterization of the characters play their part as well. If I were to make a list of my favorites, I would say Zoidberg, Zapp Brannigan, Bender, Nixon, Mom, and the Hedonismbot (I would also mention the Hypnotoad, who makes brief but hilarious appearances).  
Overall, Futurama is a masterpiece animated series that satisfies, one way or another, practically all types of viewers: from lovers of comic situations to those who enjoy satire (political, religious, social), to those who like references (and if you pay close attention, there are tons of them) to those who prefer time paradoxes. Of course, there are some missteps (as happens in all things created by humans) but they remain small imperfections in a masterful whole.   What can I say, highly recommended for everyone, of all genders and ages, whether as occasional entertainment or as a most enjoyable commitment (although I strongly advise following the latter path). I bet you won't be disappointed and that in the end, you too will exclaim "What a fixation!" like good Fry.   
Ah, sorry! I forgot to mention that the series is also suitable for a sentimental audience... Don't believe it? Then watch the episodes "Jurassic Bark" and "The Luck of the Fryrish" and then come and tell me if a tear didn't escape... and if this series doesn't deserve the label of a masterpiece.
P.S. I have deliberately avoided comparisons with the "Simpsons" to evade the usual arguments about which is the better or worse cartoon. Enjoy both of them, each for their characteristics, and you'll live happily ever after.